The FRAMATOME (formerly AREVA NP) global HFE team ensures the suitability of modernized and new-build plants design for reliable operation and maintenance. The paper provides insights into the current work portfolio, innovations in HMI and usability testing, and advances in Reliability Engineering. The followed approach towards reliable plant operation, the analysis, design guidance, and evaluation methods thereby applied, and the practice of their use - aided by the evolving database of operator tasks and task support characteristics required for reliable task completion - are described.