Designing piping systems for nuclear power plants involves engineers from multiple disciplines (i.e., thermal hydraulics, mechanical engineering, and structural/seismic) and close coordination with the contractors who build the plant. Any design changes during construction need to be carefully communicated and managed with all stakeholders in order to assess risks associated with the design changes. To allow the quick assessment of building and piping design changes through a streamlined building-piping coupled analysis, this paper presents a novel interoperability solution that converts bidirectionally between building information models (BIMs) and pipe stress models. Any design changes during construction that are shown in an as-built BIM are automatically converted into a pipe stress model. Any further design changes due to building-piping interaction analyses are converted back to the BIM for the contractor and other designers to access the latest model. Two case studies are presented to illustrate the bidirectional conversion that allows an integrated coupled analysis of the building-piping system to account for their interactions.