Westinghouse and TerraPower, in conjunction with Belgium’s Pan Tera, have announced plans to produce large quantities of actinium-225, a radioisotope used for targeted alpha radiation therapy for certain types of cancer.

Serva Energy has developed a research reactor–based method of actinium-225 production, the company announced on June 22, saying it “marks the first time a commercial entity has employed a conventional nuclear reactor to produce the lifesaving isotope—allowing for dozens of existing research reactors around the world to collaborate with Serva on increasing production of Actinium-225 without huge capital investments or delays for construction.”

This vial contains traces of actinium within a mixture of thorium and uranium. Photo: Isotek

An article recently published in Chemical & Engineering News describes TerraPower’s efforts to extract actinium-225, a radioisotope with therapeutic potential, from highly radioactive uranium-233 owned by the Department of Energy and slated for disposal. While others are working to ramp up production of Ac-225 by using a linear accelerator or cyclotron, TerraPower hopes to harvest between 200,000 and 600,000 doses a year from U-233 to increase the global supply.