A new analytical laboratory at Oak Ridge National Laboratory has been officially opened by the Department of Energy’s Oak Ridge Office of Environmental Management and its contractor Isotek Systems. The state-of-the-art lab, located in Building 2026, is being used to speed up the high-priority cleanup of ORNL’s uranium-233 inventory and accelerate the delivery of actinium-225 to facilities that use the radioisotope in research and for potential treatment of patients with cancer.

Westinghouse and TerraPower, in conjunction with Belgium’s Pan Tera, have announced plans to produce large quantities of actinium-225, a radioisotope used for targeted alpha radiation therapy for certain types of cancer.

Serva Energy has developed a research reactor–based method of actinium-225 production, the company announced on June 22, saying it “marks the first time a commercial entity has employed a conventional nuclear reactor to produce the lifesaving isotope—allowing for dozens of existing research reactors around the world to collaborate with Serva on increasing production of Actinium-225 without huge capital investments or delays for construction.”

This vial contains traces of actinium within a mixture of thorium and uranium. Photo: Isotek

An article recently published in Chemical & Engineering News describes TerraPower’s efforts to extract actinium-225, a radioisotope with therapeutic potential, from highly radioactive uranium-233 owned by the Department of Energy and slated for disposal. While others are working to ramp up production of Ac-225 by using a linear accelerator or cyclotron, TerraPower hopes to harvest between 200,000 and 600,000 doses a year from U-233 to increase the global supply.