Time-dependent sensitivity techniques, which have been used in the past for standard reactor applications, are adapted to calculate the impact of data uncertainties and to estimate target data accuracies in radiotoxicity evaluations. The methodology is applied to different strategies of radioactive waste management connected with the European Fast Reactor and the Integral Fast Reactor fuel cycles. Results are provided in terms of sensitivity coefficients of basic data (cross sections and decay constants), uncertainties of global radiotoxicity at different times of storing after discharge, and target data accuracies needed to satisfy maximum uncertainty limits.