This paper is devoted to the concept of combined thermonuclear plant with a reactor-laser driver for industrial electric energy production, based on the inertial plasma confinement. The plant is referred to as “combined” since in its functional diagram and design the elements of nuclear and thermonuclear systems are combined. As far as its economy is concerned, that is based on both nuclear and thermonuclear fuel cycles. The concept proposed is shown to be realistic from the point of view of its practical realization and vital in terms of the increase of nuclear power efficiency and ecological safety.