Neutronics activities for the next generation devices are the subject of this paper. The main activities include TFCX and FPD blanket/shield studies, neutronics aspects of ETR/INTOR critical issues, and neutronics computational modules for the tokamak system code and tandem mirror reactor system code. Trade-off analyses, optimization studies, design problem investigations and computational models development for reactor parametric studies carried out for these activities are summarized.