As the volume ignition of deuterium-helium-3 (D-3He) and deuterium-deuterium (D-D) fuels has been numerically modeled, the nuclear fusion reaction , including the secondary D(d,n) He and D(d,p) reactions, is now investigated, and its energy efficiency and ignition conditions are examined. For the first time, it is shown that although the n/D-3He ratio depends on volume and density, this ratio is small and nearly the same for different pellet volumes and pellet concentrations for conditions where pellet ignition occurs. Also, the inclusion of the D-D reactions increases the fusion gain and significantly changes the ignition conditions.