The HYLIFE-II inertial confinement fusion reactor uses a Flibe spray for blast chamber protection and tritium breeding. HYLIFE-II is passively safe, having no large sources of energy available to disperse radioactive materials. The dominant activation product is 18F (half-life 110 minutes). Only a small fraction (<10−5) of the Flibe activation products would be mobilized. The offsite dose from a severe accident involving simultaneous failure of the blast chamber and containment building would be < 0.2 mSv (20 mrem), and N-stamp requirements could be avoided in the blast chamber and coolant systems. The required tritium removal efficiencies are quantified.