The Lawrence Livermore National Laboratory intends to upgrade the Nova Laser Facility to ∼2 MJ of blue light. Our first step in ensuring strict adherence to environmental, safety, and health guidelines is to explore the radiological aspects of Nova Upgrade. The results of neutron activation and radiation dose calculations are presented for two different chamber designs: an aluminum chamber with a water blanket for shielding and a high purity, fiberglass epoxy chamber. In addition to the activation of the chamber materials, we address the activation and resulting radiological hazards of the beam tubes, optical elements in the beam lines, concrete walls, aluminum space frame, and air surrounding the chamber. We report the peak prompt dose just outside the concrete walls that surround the chamber. Tritium recovery and disposal techniques are also addressed.