Results of 233U production rate measurements conducted in a vertical assembly of thorium oxide rods irradiated by high-intensity 14-MeV neutrons generator of the LOTUS facility are presented. The amount of 233U produced is determined by measuring the yield of 233Pa. Moreover, a method is presented to estimate the global 233U production in the blanket module from a limited number of point reaction rates measured throughout the module. The experimental data are compared with the results of preliminary two-dimensional calculations.