An analysis of the heat transport and water detritiation systems of ITER has been performed in order to determine major pathways for tritium loss and estimate releases during normal operation (operational tritium release). Heavy water escape and tritium release estimates compiled on the basis of operating experiences of typical CANDU PWR and the Darlington Tritium Removal Facility (DTRF) have been appropriately scaled on the basis of water and tritium inventories and tritium concentrations to fit ITER design and operating conditions. The paper estimates the chronic and acute tritium releases to the environment in elemental and oxide forms, via waterborne and airborne pathways of the ITER water systems. The results of the analysis will be used to demonstrate that the ITER design will meet the dose limits for occupational and accidental tritium releases.