The Tandem Mirror Hybrid Reactor is a fusion reactor concept that incorporates a fission-suppressed breeding blanket for the production of 233U to be used in conventional fission power reactors. The present paper reports on compatibility considerations related to the blanket design. These considerations include solid-solid interactions and liquid metal corrosion. Potential problems are discussed relative to the reference blanket operating temperature (490°C) and the recycling time of fissile materials (<1 year).