The three sets of hydrophobic catalyst and inert packing material for Liquid Phase Catalytic Exchange (LPCE) column have been tested for tritium isotopic exchange between liquid water and gaseous hydrogen. It was observed that wettability of the packing material was a crucial parameter for overall performance of the column. Provided that the packing is sufficiently wet, different hydrophobic catalyst/packing sets exhibit similar throughput and efficiency of isotopic exchange.