A series of design scoping and fuel cycle studies for sub-critical fast transmutation reactors driven by tokamak fusion neutron sources has been carried out to determine if the requirements on the tokamak neutron sources are compatible with the fusion physics and technology design database that will exist after the operation of ITER and to determine if there is a significant advantage in fuel cycle flexibility due to sub-critical operation that would justify the additional cost and complexity of a fusion neutron source. The fast reactor technologies are based on reactor concepts being developed in the DoE Generation-IV and Advanced Fuel Cycle initiatives.