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Latest News
Framatome signs contracts with Sizewell C
French nuclear developer Framatome is slated to deliver key equipment for Sizewell C Ltd.’s two large reactors planned for the United Kingdom’s Suffolk coast.
The agreement, reportedly worth multiple billions of euros, was announced this week and will involve Framatome from the design phase until commissioning. The company also agreed to a long-term fuel supply deal. Framatome is 80.5 percent owned by France’s EDF and 19.5 percent owned by Mitsubishi Heavy Industries.
Tsutomu Shimura, Yoshikazu Kuwahara, Manabu Fukumoto, Toshiyuki Umata
Fusion Science and Technology | Volume 60 | Number 3 | October 2011 | Pages 1190-1192
Biology | Proceedings of the Ninth International Conference on Tritium Science and Technology | doi.org/10.13182/FST11-A12628
Articles are hosted by Taylor and Francis Online.
Tritium is used as fuel for nuclear fusion reactions and has cancer risk for workers in nuclear fusion plant by its exposure during routine operation or accidents. Tritium exists as tritiated water (HTO) which is produced by an isotope exchange reaction from HT in normal circumstance. In this study we analyzed cellular response against HTO exposure in a human liver cancer cell line HepG2 and a cervical cancer cell line HeLa. These cells were immersed in RPMI medium containing HTO at the dose rate of 0.5 Gy/hr for 20 hrs (10 Gy). We determined whether the DNA-PK/AKT pathway is activated by chronic HTO exposure or not. As well as X-rays, exposure of HepG2 and HeLa cells to HTO activated AKT, which was shown by phosphorylated-AKT at Serine473. The activation of DNA-PK was also observed in these cells by X-ray irradiation but not by exposure to HTO. Instead of DNA-PK, epidermal growth factor receptor and ERK1/2 were activated following HTO exposure. These results suggested that certain cellular molecules are response to HTO exposure. Our study may provide molecular markers to estimate the biological effects in response to tritium exposure in human cells.