The recent trend for nuclear safety-related instrumentation and control (I&C) applications is that field programmable gate array (FPGA) technology is being used more frequently. Software verification and validation (V&V) activities are used to provide objective evidence that the software and its associated products and processes conform to requirements (e.g., for correctness, completeness, consistency, and accuracy). Standards are used to provide accepted practices and conventions for software V&V activities. Regulators rely on industry standards to support their review of digital I&C systems used for safety-related applications. A key challenge for the review of FPGA-based I&C systems in the United States is the use of IEEE Std 1012-2004 to develop the appropriate software V&V plan. The Nuclear Regulatory Commission (NRC) endorses IEEE Std 1012-2004 as an acceptable approach for meeting the agency’s regulatory requirements on the V&V of safety system software. The software-centric nature of IEEE Std 1012 is a limitation on its effectiveness in establishing a common framework for V&V processes, activities, and tasks in support of FPGA-based development processes. The use of IEEE Std 1012 to define the V&V requirements for FPGA-based I&C applications will always require the standard requirements to be tailored and adapted to the FPGA technology. The required adaptations limit the usefulness of the standard to support efficient reviews of safety-related I&C applications by the NRC, since adaptations made for each project must be reviewed for technical adequacy. The paper makes recommendations to on the use of IEEE Std 1012 with FPGA technology and to improve the regulatory framework for FPGA-based projects based on a case study involving a digital I&C platform developed using IEC standards.