The leakage jet impact effect of steam generator heat exchanger piping causes the vibration response of adjacent piping and secondary sound radiation. This study establishes a three-dimensional numerical calculation model of a leakage jet impacting the pipe wall and studies in depth the action mechanism of the leakage jet on the adjacent pipe wall. It obtains the vibration characteristics of the pipe wall caused by the impact of the leakage jet. Calculations show that the leakage jet excites a complex flow field on the surface of the adjacent pipe wall, generating dynamic pressure loads and shear stresses. Dynamic pressure loads generate significant negative pressure wave signals on adjacent pipe walls, which in turn trigger pipe wall vibrations. With an increase in the leakage hole diameter and internal pressure, the dynamic load on the pipe wall increases significantly, leading to obvious changes in the vibration characteristics, revealing the influence law of the leakage jet on the dynamic response of the pipe wall.