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Radium sources yield cancer-fighting Ac-225 in IAEA program
The International Atomic Energy Agency has reported that, to date, 14 countries have made 14 transfers of disused radium to be recycled for use in advanced cancer treatments under the agency’s Global Radium-226 Management Initiative. Through this initiative, which was launched in 2021, legacy radium-226 from decades-old medical and industrial sources is used to produce actinium-225 radiopharmaceuticals, which have shown effectiveness in the treatment of patients with breast and prostate cancer and certain other cancers.
Akio Yamamoto, Kuniharu Kinoshita, Tomoaki Watanabe, Tomohiro Endo, Yasuhiro Kodama, Yasunori Ohoka, Tadashi Ushio, Hiroaki Nagano
Nuclear Science and Engineering | Volume 181 | Number 2 | October 2015 | Pages 160-174
Technical Paper | doi.org/10.13182/NSE14-152
Articles are hosted by Taylor and Francis Online.
Uncertainties of various neutronics characteristics in commercial boiling water reactor (BWR) and pressurized water reactor (PWR) cores due to cross-section covariance are evaluated by the Latin Hypercube Sampling (LHS) method, which is an efficient random sampling algorithm. Thermal-hydraulic feedback and burnup effects are fully and explicitly taken into account using a licensing-grade core simulator. Uncertainties for various core characteristics are evaluated by the statistical processing of core calculation results based on the LHS method. The calculation results indicate that uncertainty of critical eigenvalue (i.e., core reactivity) in the BWR core is comparable to that of a typical PWR core. On the other hand, uncertainties of assembly relative power distribution and maximum assembly burnup in the present BWR core are much smaller than those of the present PWR core. The strong thermal-hydraulic feedback effect in the BWR core significantly contributes to the difference of uncertainties in BWR and PWR cores.