Following the success of the past meetings, the PHYSOR topical meeting is back in Pittsburgh. PHYSOR 2022 will focus on the future of reactor physics and related nuclear technologies. The meeting aims to provide a platform for international experts from vendors, utilities, research laboratories, and universities to exchange ideas and latest developments on a wide spectrum of topics. Technical sessions include standard topics of interest as well as special sessions including novel analysis methods, advanced reactor designs, machine learning and artificial intelligence applications, high enrichment/high burnup core design challenges, space nuclear technologies, and high-performance computing. The meeting will also include plenary sessions focusing on advanced reactor design development and demonstration programs, panel sessions, and several workshops on state-of-the-art reactor physics tools.