Framatome is developing a realistic non-LOCA safety evaluation methodology to assess PWR plant response under accident conditions based on coupled multi-physics simulations employing a 3D transient core simulator, a 3D core thermal-hydraulics, a system thermal-hydraulics and a fuel thermal-mechanical codes. Industrial deployment of such complex methodology required the development of an advanced execution platform capable of integrating multi-physics simulation codes while providing flexibility to express the methodology processes through a modular platform design. The execution platform architecture relies on versatile building blocks with functionality entirely controlled through user inputs. The platform offers deterministic parameter modeling and statistical parameter uncertainty sampling for simulation code inputs to define Design of Experiments and Monte Carlo evaluations whose management and execution uses an optimized Directed Acyclic Graph algorithm capable of handling a large number of simulations and seamlessly interfacing with High Performance Computing job schedulers.