Decommissioning of a nuclear power plant involves the safe disposition of a large quantity of radioactive, hazardous and conventional waste. A number of nuclear power plant decommissioning projects have been completed or are nearing completion in the US, Germany and Spain. These projects have used various waste disposal and interim storage options, and have developed successful methods for handling the large quantities of waste created by the decommissioning. Additionally, decommissioning projects in several Asian and European countries are in progress or are in the planning stages such that strategies for the handling of decommissioning waste are being developed and/or implemented to address the regulatory requirements and disposal options available in these countries. These experiences provide important lessons learned and successful strategies for the handling of waste from power plant decommissioning projects. As the handling and disposition of decommissioning waste have a substantial effect on power plant decommissioning cost, schedule and complexity, these lessons learned are valuable for planning future decommissioning projects.