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Radium sources yield cancer-fighting Ac-225 in IAEA program
The International Atomic Energy Agency has reported that, to date, 14 countries have made 14 transfers of disused radium to be recycled for use in advanced cancer treatments under the agency’s Global Radium-226 Management Initiative. Through this initiative, which was launched in 2021, legacy radium-226 from decades-old medical and industrial sources is used to produce actinium-225 radiopharmaceuticals, which have shown effectiveness in the treatment of patients with breast and prostate cancer and certain other cancers.
Brock Jolicoeur, Norbert Hugger, David Medich
Nuclear Technology | Volume 209 | Number 11 | November 2023 | Pages 1819-1825
Regular Research Article | doi.org/10.1080/00295450.2023.2204988
Articles are hosted by Taylor and Francis Online.
We investigate the image quality and beam intensity of thermal neutron radiography after replacing a standard single-channel neutron collimator with a compact array of microcollimators. In this study, the MCNP6 Monte Carlo computer code was used to simulate a 2 × 2-cm-area isotropic thermal neutron source, which then was collimated by an array of micron-sized neutron collimators that measured 29.8 μm in diameter and with lengths that varied from 0.6 to 3 mm. These microcollimators were spaced 30 μm apart and assembled into a 2 × 2-cm array.
The image quality of the neutron beams produced by the resulting collimator arrays was assessed by imaging the edge of a very thin (~0.01-mm) gadolinium foil to obtain the image Modulation Transfer Function (MTF). The MCNP6 resulting flux map from each simulation then was converted into a grayscale .tiff image and the image’s resulting MTF obtained using the ImageJ computer program with the imaging beam geometric unsharpness, which is a limiting factor in the image resolution determined at the 10% value of the MTF curve.
In this study, we found that a 2 × 2× 0.298-cm microcollimator, corresponding to a length-to–hole diameter ratio of 100:1 and a collimator length of 2.98 mm produced a beam with a geometric unsharpness of 32 μm. Compared to a standard single-channel collimator with a 2 × 2-cm aperture, the single-channel collimator would need to be 660 cm long to produce an equivalent geometric sharpness. Yet because of its shorter length, the imaging beam intensity from our 2.98-mm-thick collimator array was approximately 50 times greater than that of an equivalent single-channel collimator.