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Radium sources yield cancer-fighting Ac-225 in IAEA program
The International Atomic Energy Agency has reported that, to date, 14 countries have made 14 transfers of disused radium to be recycled for use in advanced cancer treatments under the agency’s Global Radium-226 Management Initiative. Through this initiative, which was launched in 2021, legacy radium-226 from decades-old medical and industrial sources is used to produce actinium-225 radiopharmaceuticals, which have shown effectiveness in the treatment of patients with breast and prostate cancer and certain other cancers.
Taiyang Zhang, Caleb S. Brooks
Nuclear Technology | Volume 209 | Number 10 | October 2023 | Pages 1414-1441
Research Article | doi.org/10.1080/00295450.2022.2151823
Articles are hosted by Taylor and Francis Online.
Natural circulation is employed in new designs of light water reactors to enhance passive safety by maintaining flow and heat removal without pumps. Under low-pressure and low-flow-rate conditions, natural circulation is susceptible to two-phase instabilities leading to undesirable flow oscillations and operational difficulties. Flashing instability is one of the most widely reported low-pressure natural circulation instabilities, related to saturated vaporization triggered by a hydrostatic pressure drop in an adiabatic riser above a heated section. While existing studies have reported flashing instability experiments, modeling, and simulations including successes in matching numerical results and experimental data, solid yet clear analytical explanations for many of its qualitative features are still rare. To enhance the physical understanding beyond stability boundary prediction, the current work develops, validates, and analyzes a linear stability model of flashing instability. This model adopts a one-dimensional Drift-Flux Model simplified by physical assumptions and approximations, and it includes optional component models to match an actual facility for validation. Stability tests are performed on a 5-m-tall natural circulation loop, providing comprehensive benchmark data covering stability boundaries, one-dimensional transient signals, and periodic mean waveforms from local measurements. Validation confirms acceptable predictions of steady states, stability boundaries, and oscillation periods. The tractable model formulation leads to a closed-form characteristic function facilitating analytical manipulations and physical interpretations, based on which dominant pressure drop responses to inlet flow rate are extracted. The major instability mechanism is identified as a strong response of the two-phase driving force to the inlet flow rate that is delayed by enthalpy transportation through a long single-phase distance and can become an overwhelmingly destabilizing positive feedback under low-frequency perturbations. Experimentally reported qualitative features, including stability changes, timescale relations, and oscillation patterns, are analytically predicted and physically explained with clarity. In general, this study enriches experimental resources of flashing instability with a comprehensive dataset and provides a simple yet realistic analytical basis for physically understanding flashing instability beyond predicting stability boundaries.