The digital control system (DCS)+state-oriented procedure (SOP) system adopted by China’s Ling’ao Phase II nuclear power plant’s main control room requires changes to the cognitive process, behavior mode, and error mode while triggering new human factors. Therefore, in this paper we present a cognitive reliability model for the DCS+SOP system in the Ling’ao Phase II Nuclear Power Plant’s main control room and conduct a human reliability analysis. The model is based on the cognitive process with respect to considering the coordinator’s accident recovery effect and obtaining the method of calculating cognitive reliability. We determine impact factors for the three cognitive stages of the operator’s and the coordinator’s diagnosis, decision making, and operation. We obtain the operator’s and the coordinator’s weights for each process through an analytic hierarchy process. Using methods of simulation and analyzing the experiment data, we obtain revised coefficients for the cognitive reliability model. Additionally, the trend of the simulation curve indicates the rationality of the model. Finally, we provide an example based on the proposed cognitive reliability model. The process of analyzing the example demonstrates that this method provides a feasible analysis method for the cognitive reliability of the DCS+SOP system in the main control room.