The performance and eligibility of the fiber optic laser-induced breakdown spectroscopy (FO-LIBS) instrument will be primarily evaluated at the Advanced Spent Fuel Conditioning Process Facility (ACPF), where spent nuclear fuel is processed in a high-temperature molten salt bath using electrochemical methods. The damage incurred by the optical fiber cable due to radiation should be addressed to ensure the reliability of FO-LIBS measurements. High-level and low-level gamma ray and neutron irradiation experiments were conducted to measure the effect of radiation on the optical transmission rate of the optical fiber cable. Conclusively, we determined the dependence of the transmission rate of the cable on the radiation dose rate as a function of the wavelength.