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Conference Spotlight
Nuclear Energy Conference & Expo (NECX)
September 8–11, 2025
Atlanta, GA|Atlanta Marriott Marquis
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Chris Wagner: The role of Eden Radioisotopes in the future of nuclear medicine
Chris Wagner has more than 40 years of experience in nuclear medicine, beginning as a clinical practitioner before moving into leadership roles at companies like Mallinckrodt (now Curium) and Nordion. His knowledge of both the clinical and the manufacturing sides of nuclear medicine laid the groundwork for helping to found Eden Radioisotopes, a start-up venture that intends to make diagnostic and therapeutic raw material medical isotopes like molybdenum-99 and lutetium-177.
Robert W. Rice, John C. Walton
Nuclear Technology | Volume 163 | Number 1 | July 2008 | Pages 15-23
Technical Paper | High-Level Radioactive Waste Management | doi.org/10.13182/NT08-A3965
Articles are hosted by Taylor and Francis Online.
A numerical experiment was performed in order to examine the ability of multiple Monte Carlo realizations of a numerical model to reproduce the risk from a hypothetically known waste disposal situation. In the analysis, the risk was summarized by several risk metrics that could be chosen by a regulatory agency to set a risk standard. In the numerical experiment, the parameters in the numerical model are systematically varied to adjust bias (conservative or nonconservative) and to increase uncertainty relative to the hypothetically known future. The influence of parameter bias and uncertainty on the accuracy of each risk metric in predicting the nominal risk was evaluated and presented graphically. These analyses concluded that the peak-of-the-mean metric provides the least stable and least accurate risk predictions, whereas the cumulative release metric and mean of the peaks are more stable and accurate. The peak-of-the-mean and peak-of-the-median metrics exhibit risk dilution (i.e., a decrease in the predicted risk with increased uncertainty) and tend to underpredict risk. Additionally, these results illustrated how risk predictions that are made using what may be considered "conservative" assumptions can be moved in a direction that may or may not be expected or intended. Simulation relative to a hypothetical future (i.e., the nominal case) provides insight into the numerical behavior and potential accuracy of our risk assessment tools and potential issues with setting regulatory standards.