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Nuclear Energy Conference & Expo (NECX)
September 8–11, 2025
Atlanta, GA|Atlanta Marriott Marquis
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Chris Wagner: The role of Eden Radioisotopes in the future of nuclear medicine
Chris Wagner has more than 40 years of experience in nuclear medicine, beginning as a clinical practitioner before moving into leadership roles at companies like Mallinckrodt (now Curium) and Nordion. His knowledge of both the clinical and the manufacturing sides of nuclear medicine laid the groundwork for helping to found Eden Radioisotopes, a start-up venture that intends to make diagnostic and therapeutic raw material medical isotopes like molybdenum-99 and lutetium-177.
Neil E. Todreas, Philip E. MacDonald, Pavel Hejzlar, Jacopo Buongiorno, Eric P. Loewen
Nuclear Technology | Volume 147 | Number 3 | September 2004 | Pages 305-320
Technical Paper | Medium-Power Lead-Alloy Reactors | doi.org/10.13182/NT04-A3534
Articles are hosted by Taylor and Francis Online.
A multiyear project at the Idaho National Engineering and Environmental Laboratory and the Massachusetts Institute of Technology investigated the potential of medium-power lead-alloy-cooled technology to perform two missions: (1) the production of low-cost electricity and (2) the burning of actinides from light water reactor (LWR) spent fuel. The goal of achieving a high power level to enhance economic performance simultaneously with adoption of passive decay heat removal and modularity capabilities resulted in designs in the range of 600-800 MW(thermal), which we classify as a medium power level compared to the lower [~100 MW(thermal)] and higher [2800 MW(thermal)] power ratings of other lead-alloy-cooled designs. The plant design that was developed shows promise of achieving all the Generation-IV goals for future nuclear energy systems: sustainable energy generation, low overnight capital cost, a very low likelihood and degree of core damage during any conceivable accident, and a proliferation-resistant fuel cycle. The reactor and fuel cycle designs that evolved to achieve these missions and goals resulted from study of the following key trade-offs: waste reduction versus reactor safety, waste reduction versus cost, and cost versus proliferation resistance. Secondary trade-offs that were also considered were monolithic versus modular design, active versus passive safety systems, forced versus natural circulation, alternative power conversion cycles, and lead versus lead-bismuth coolant.These studies led to a selection of a common modular design with forced convection cooling, passive decay heat removal, and a supercritical CO2 power cycle for all our reactor concepts. However, the concepts adopt different core designs to optimize the achievement of the two missions. For the low-cost electricity production mission, a design approach based on fueling with low enriched uranium operating without costly reprocessing in a once-through cycle was pursued to achieve a long operating cycle length by enhancing in-core breeding. For the actinide-burning mission three design variants were produced: (1) a fertile-free actinide burner, i.e., a single-tier strategy, (2) a minor actinide burner with plutonium burned in the LWR fleet, i.e., a two-tier strategy, and (3) an actinide burner with characteristics balanced to also favor economic electricity production.