ENEA began work on seismic isolation in Italy in 1988 in cooperation with ISMES. Until now, work has been limited to horizontal systems and focused on high-damping steel-laminated elastomer bearings. Work consists of both the assessment of proposed design guidelines for isolated nuclear reactors (developed in collaboration with General Electric Company) and research and development (R&D) experimental and numerical studies, partly performed in support of the guideline development. Experiments include static and dynamic characterization of single bearings, analysis of a full-scale isolated structure and an actual building with in situ techniques, and shake table tests of scaled isolated structures. The main features of the guidelines document and R&D studies are described, and some initial measured data are presented.