Probabilistic risk assessment (PRA) based inspection guidance has been developed using information from the PRA for Arkansas Nuclear One Unit 1 (ANO-1). This information will be used in conjunction with the U.S. Nuclear Regulatory Commission (NRC) Inspection and Enforcement Manual and has been prepared in the form of a plant-specific appendix for incorporation into this manual. An analytical method was developed for calculating risk importance for affected plant systems. This was used to prioritize the ANO-1 plant systems using the Fussel- Vesely importance measure on the basis of core melt probability. System fault trees were reanalyzed to identify and rank the risk significant components in each system. The product of this effort is a prioritized listing of systems and components associated with 98% of the inspectable portion of the risk from ANO-1. This compilation will subsequently be used by NRC inspectors in the preparation of inspection plans addressing risk-important systems and components at the ANO-1 power plant.