This study examines the economics of the DUPIC fuel cycle using unit costs of fuel cycle components estimated based on conceptual designs. The fuel cycle cost (FCC) was calculated by a deterministic method in which reference values of fuel cycle components are used. The FCC was then analyzed by a Monte Carlo simulation to get the uncertainty of the FCC associated with the unit costs of the fuel cycle components. From the deterministic analysis on the equilibrium fuel cycle model, the DUPIC FCC was estimated to be 6.21 to 6.34 mills/kWh for DUPIC fuel options, which is a little smaller than that of the once-through FCC by 0.07 to 0.27 mills/kWh. Considering the uncertainty (0.40 to 0.44 mills/kWh) of the FCC estimated by the Monte Carlo simulation method, the cost difference between the DUPIC and once-through fuel cycle is negligible. On the other hand, the material balance calculation has shown that the DUPIC fuel cycle can save natural uranium resources by ~20% and reduce the spent fuel arising by ~65% compared with the once-through fuel cycle. In conclusion, the DUPIC fuel cycle is comparable with the once-through fuel cycle from the viewpoint of FCC. In the future, it should be important to consider factors such as the environmental benefit owing to natural uranium savings, the capability of reusing spent pressurized water reactor fuel, and the safeguardability of the fuel cycle when deciding on an advanced nuclear fuel cycle option.