A system has been developed for the production of 99mTc based on distributed electron accelerators and thermal separation. The radioactive decay parent of 99mTc, 99Mo, is produced from 100Mo by a photoneutron reaction. Two alternative thermal separation processes have been developed to extract 99mTc. Experiments have been performed to verify the technical feasibility of the production and assess the efficiency of the extraction processes. A system based on this technology enables the economical supply of 99mTc for a large nuclear pharmacy. Twenty such production centers distributed near major metropolitan areas could produce the entire U.S. supply of 99mTc at a cost less than the current subsidized price.