A numerical simulation of the interaction between two real pressurized water reactor containment sprays is performed with a new model implemented into the Eulerian computational fluid dynamics (CFD) code NEPTUNE_CFD. The water droplet polydispersion in size has been treated with a sectional approach. The influence of collisions between droplets is taken into account with a statistical approach based on the various outcomes of binary collision. Experiments were performed in a new facility, and data obtained are compared with this two-fluid simulation. The results show good agreement.