The Fluoride salt–cooled High-temperature Reactor (FHR) is a Generation IV reactor concept that can operate under near atmospheric pressure circumstances and further enhance inherent safety. In this study, an FHR core design with 165 MW of thermal output [MW(thermal)] is proposed. The reactor core employs tristructural-isotropic (TRISO) particle fuel within prismatic graphite blocks as the basic fuel form, FLiBe [lithium-beryllium fluoride (2 7LiF-BeF2)] as the primary coolant, and a three-batch fuel cycle scheme. Sensitivity analyses on various parameters were performed to optimize the cycle length and neutronic parameters. The fuel cycle of this core design was evaluated in detail from four aspects: cycle length, power peaking factor (PPF), discharge burnup, and temperature coefficient. It was found that a larger fuel channel pitch would have a relatively harder neutron spectrum and yield a relatively longer cycle length, lower PPF, and better fuel temperature coefficient and moderator temperature coefficient (MTC). In addition, burnable poison (BP) (Er2O3) can effectively reduce PPF, hold down the multiplication factor, and more importantly it can improve the MTC. The preliminary design of control blades is also presented in this paper. Furthermore, on the basis of the proposed 165-MW(thermal) core, we propose a novel core design that incorporates “fuel inside radial moderator (FIRM)” assemblies, movable moderator, and movable BP. This new design can extend the fuel cycle length by approximately 45 days for an 18-month fuel cycle. In addition, improvements were also found in PPF, discharge burnup, and temperature coefficients.