In this paper, a beta radioluminescent battery with different radioisotopes is studied, and different parameters of the proposed structure are optimized. These parameters include the luminescent layer thickness, the doping concentration in the semiconductor P-N junction, etc. Some of the parameters have an inverse effect on the battery outputs. So, a trade-off is sought between them to increase efficiency. Each part of the proposed structure is divided into much smaller parts in the simulations to ensure proper tracking of photons and the creation of electron holes in the semiconductor layer. Also, the passage of particles through each layer is carefully reviewed and calculated in terms of particle crossing percentage, their reflection percentage, rate of self-absorption, etc. Finally, the power, open-circuit voltage, and short-circuit current density of the proposed battery versus the main parameter changes are presented.