At present, no clear guidelines exist for modeling non-water-cooled small modular reactors (SMRs) despite the rising need for high-fidelity simulation tools to support regulators and the industry. Most SMR concepts currently under the Canadian prelicensing review adopted non-water-cooled–reactor technologies [molten salt reactor (MSR), gas-cooled reactor, and liquid metal–cooled reactor] that are new for Canada. There is a need for a modeling tool set that is broadly applicable for the assessment of advanced technologies used in SMRs. Computational fluid dynamics (CFD) can be used in performance evaluation and safety analysis of non-water-cooled SMRs for modeling three-dimensional (3-D) fluid flow and heat transfer in geometries of arbitrary complexity without resorting to geometry-specific empirical correlations. This study investigates the capabilities of existing models within a commercial CFD code to simulate the flow and heat transfer characteristics in a MSR configuration. The Oak Ridge National Laboratory (ORNL) Molten Salt Reactor Experiment (MSRE) configuration was simulated in this study using a stand-alone CFD approach, and CFD predictions were assessed with ORNL data. Intricate geometry details within the MSRE core were included in the computational model to study the associated geometric effects. The results obtained in this study showcased the ability of CFD to predict 3-D effects within the computational domain especially at the lower plenums. The predicted trends for the temperature rise in the fuel and moderator within the core were in good agreement with the ORNL data. The results presented in this paper constitute the first step in developing Canadian Nuclear Laboratories’ capability for CFD modeling of non-water SMRs.