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Radium sources yield cancer-fighting Ac-225 in IAEA program
The International Atomic Energy Agency has reported that, to date, 14 countries have made 14 transfers of disused radium to be recycled for use in advanced cancer treatments under the agency’s Global Radium-226 Management Initiative. Through this initiative, which was launched in 2021, legacy radium-226 from decades-old medical and industrial sources is used to produce actinium-225 radiopharmaceuticals, which have shown effectiveness in the treatment of patients with breast and prostate cancer and certain other cancers.
Matthew Ellis, Derek Gaston, Benoit Forget, Kord Smith
Nuclear Science and Engineering | Volume 185 | Number 1 | January 2017 | Pages 184-193
Technical Paper | doi.org/10.13182/NSE16-26
Articles are hosted by Taylor and Francis Online.
In recent years, the use of Monte Carlo methods for modeling reactors has become feasible due to the increasing availability of massively parallel computer systems. One of the primary challenges yet to be fully resolved, however, is the efficient and accurate inclusion of multiphysics feedback in Monte Carlo simulations. The research in this paper presents a preliminary coupling of the open-source Monte Carlo code OpenMC with the open-source Multiphysics Object-Oriented Simulation Environment (MOOSE). The coupling of OpenMC and MOOSE will be used to investigate efficient and accurate numerical methods needed to include multiphysics feedback in Monte Carlo codes. An investigation into the sensitivity of Doppler feedback to fuel temperature approximations using a two-dimensional 17 × 17 pressurized water reactor (PWR) fuel assembly is presented in this paper. The results show a functioning multiphysics coupling between OpenMC and MOOSE. The coupling utilizes functional expansion tallies to transfer accurately and efficiently pin power distributions tallied in OpenMC to unstructured finite element meshes used in MOOSE. The two-dimensional PWR fuel assembly case also demonstrates that for a simplified model, the pin-by-pin Doppler feedback can be adequately replicated by scaling a representative pin based on pin relative powers.