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Radium sources yield cancer-fighting Ac-225 in IAEA program
The International Atomic Energy Agency has reported that, to date, 14 countries have made 14 transfers of disused radium to be recycled for use in advanced cancer treatments under the agency’s Global Radium-226 Management Initiative. Through this initiative, which was launched in 2021, legacy radium-226 from decades-old medical and industrial sources is used to produce actinium-225 radiopharmaceuticals, which have shown effectiveness in the treatment of patients with breast and prostate cancer and certain other cancers.
Tiejun Zu, Chenghui Wan, Liangzhi Cao, Hongchun Wu, Wei Shen
Nuclear Science and Engineering | Volume 183 | Number 3 | July 2016 | Pages 371-386
Technical Paper | doi.org/10.13182/NSE15-96
Articles are hosted by Taylor and Francis Online.
The nuclear-data uncertainties impact the best-estimate predictions of the nuclear reactor system. In this paper, total uncertainty analyses have been performed for the TMI-1 assembly at both hot zero-power and hot full-power conditions to evaluate the impacts of nuclear-data uncertainties on the predictions of lattice calculations, based on the statistical sampling method. With an improved multigroup cross-section perturbation model, the contributions of various basic cross sections to the uncertainties of k∞ and two-group macroscopic cross sections are obtained. For the total uncertainty analyses, a 172-group cross-section covariance library produced from ENDF/B-VII.1 is used to generate the samples for the multigroup microscopic cross-section library, and DRAGON 5.0 is applied to perform lattice calculations for each sample. The numerical results show that the relative uncertainty of k∞ can reach about 4.7‰ using the vp covariance matrix of 235U-v and 7.1‰ using the vt covariance matrix of 235U-v. The relative uncertainties of two-group macroscopic cross sections vary from about 2.9‰ (for the total cross section of the thermal group) to about 11.9‰ (for the scattering cross section from the fast group to the thermal group). Moreover, through detailed analysis toward uncertainty origins, it has been observed that 235U, 238U, 16O, and 1H are the four most significant contributors, and the uncertainties of 235U-(v, σf, σγ), 238U-(σγ, σ(n,inel), σ(n,elas), v), 16O-(σ(n,elas)), and 1H-(σ(n,elas), σγ) are the most significant cross-section contributors.