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Reimagining nuclear materials for the future of medicine
Nuclear medicine has come a long way since Henri Becquerel first observed the penetrating energy of radioactive materials in 1896. Today, technetium-99m alone is used in more than 40 million diagnostic procedures every year—from cardiovascular imaging and bone scans to cancer detection—making it the undisputed workhorse of nuclear medicine. That single statistic tells you something important: An enormous portion of modern diagnostic medicine rests on a surprisingly narrow foundation, one built around a small number of aging research reactors that were never originally designed for continuous isotope production.
G. L. Mesina, D. L. Aumiller, F. X. Buschman
Nuclear Science and Engineering | Volume 182 | Number 1 | January 2016 | Pages 1-12
Technical Paper | Special Issue on the RELAP5-3D Computer Code | doi.org/10.13182/NSE14-151
Articles are hosted by Taylor and Francis Online.
Large computer programs like RELAP5-3D solve complex systems of governing, closure, and special process equations to model the underlying physics of thermal-hydraulic systems and include specialized physics for the modeling of nuclear power plants. Further, these programs incorporate other mechanisms for selecting optional code physics, input, output, data management, user interaction, and post-processing. Before being released to users, software quality assurance requires verification and validation. RELAP5-3D verification and validation are focused toward nuclear power plant applications. Verification ensures that the program is built right by checking that it meets its design specifications, comparing coding algorithms to equations, comparing calculations against analytical solutions, and the method of manufactured solutions.
Sequential verification performs these comparisons initially, but thereafter only compares code calculations between consecutive code versions to demonstrate that no unintended changes have been introduced. An automated, highly accurate sequential verification method, based on previous work by Aumiller, has been developed for RELAP5-3D. It provides the ability to test that no unintended consequences result from code development. Moreover, it provides the means to test the following code capabilities: repeated time-step advancement, runs continued from a restart file, and performance of coupled analyses using the R5EXEC executive program. Analyses of the adequacy of the checks used in these comparisons are provided.