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Radium sources yield cancer-fighting Ac-225 in IAEA program
The International Atomic Energy Agency has reported that, to date, 14 countries have made 14 transfers of disused radium to be recycled for use in advanced cancer treatments under the agency’s Global Radium-226 Management Initiative. Through this initiative, which was launched in 2021, legacy radium-226 from decades-old medical and industrial sources is used to produce actinium-225 radiopharmaceuticals, which have shown effectiveness in the treatment of patients with breast and prostate cancer and certain other cancers.
Tuomas Viitanen, Jaakko Leppänen
Nuclear Science and Engineering | Volume 177 | Number 1 | May 2014 | Pages 77-89
Technical Paper | doi.org/10.13182/NSE13-37
Articles are hosted by Taylor and Francis Online.
The target motion sampling (TMS) temperature treatment technique, previously known as “explicit treatment of target motion,” is a stochastic method for taking the effect of thermal motion on reaction rates into account on-the-fly during Monte Carlo neutron tracking. The method is based on sampling target velocities at each collision site and dealing with the collisions in the target-at-rest frame using cross sections below the actual temperature of the nuclide or, originally, 0 K. Previous results have shown that transport with the original implementation of the TMS method requires about two to four times more CPU time than conventional transport methods, depending on the case. In the present paper, it is observed that the overhead factor may increase even above 10 in cases involving burned fuel. To make the method more practical for everyday use, some optimization is required. This paper discusses a TMS optimization technique in which the temperatures of the basis cross sections are elevated above 0 K. Comparisons show that the TMS method is able to reproduce the NJOY-based reference results within statistical accuracy, both with and without the newly implemented optimization technique. In the specific test cases, the optimization saved 35% to 83% of the calculation time, depending on the case.