The fusion environment is inherently complex, in which an adequate understanding of response from a plasma chamber system requires integrated (and in some areas coupled) analysis across multiple disciplines (neutronics, thermo-fluids, structural mechanics, electromagnetism etc). An integrated simulation predictive capability, which utilizes a computer based single CAD geometric model where a detailed simulation of the multi-physics phenomena occurring in a fusion plasma chamber system is performed, is under development and is described in this paper.