In Inertial Electrostatic Confinement (IEC) devices, a voltage difference between concentric, nearly transparent spherical grids accelerates ions to fusion-relevant velocities. The University of Wisconsin (UW) operates two IEC devices: a cylindrical aluminum chamber and a spherical, water-cooled, stainless-steel chamber, with a power supply capable of 75 mA and 200 kV. The research program aims to generate fusion reaction products for various applications, including protons for creating radioisotopes for nuclear medicine and neutrons for detecting clandestine materials. Most IEC devices worldwide, including the UW devices, presently operate primarily in a pressure range (1-10 mtorr) that allows ions to make only a few passes through the core before they charge exchange and lose substantial energy or they collide with cathode grid wires. It is believed that fusion rates can be raised by operating at a pressure where neutral gas does not impede ion flow, and a helicon ion source has been developed to explore operation at pressures of ~0.05 mtorr. The UW IEC research group uses proton detectors, neutron detectors, residual gas analyzers, and spectroscopic diagnostics. New diagnostic techniques have also been developed, including eclipse disks to localize proton production and chordwires to estimate ion fluxes using power balance.