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This division promotes the development and timely introduction of fusion energy as a sustainable energy source with favorable economic, environmental, and safety attributes. The division cooperates with other organizations on common issues of multidisciplinary fusion science and technology, conducts professional meetings, and disseminates technical information in support of these goals. Members focus on the assessment and resolution of critical developmental issues for practical fusion energy applications.
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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
A. Q. L. Nguyen, S. A. Eddinger, H. Huang, M. A. Johnson, Y. T. Lee, R. C. Montesanti, K. A. Moreno, M. E. Schoff
Fusion Science and Technology | Volume 55 | Number 4 | May 2009 | Pages 399-404
Technical Paper | Eighteenth Target Fabrication Specialists' Meeting | dx.doi.org/10.13182/FST09-18
Articles are hosted by Taylor and Francis Online.
Capsules for the National Ignition Facility require measurement of isolated defects on the capsule surface. A phase-shifting diffraction interferometer (PSDI) is used to identify, locate, and measure defects by capturing 71 overlapping ~500-m-diam charge coupled device height maps for software analysis. Using capsules with drilled holes for the purpose of alignment, PSDI data were confirmed with atomic force microscopy by comparing defect data from corresponding equatorial bands. We explored the limitations of the PSDI resulting from unwrapping errors caused by defect slopes greater than the Nyquist sampling theorem. White light interferometry proved to be a useful complementary tool to measure defects that could not be unwrapped by the analysis software. Implementing the PSDI in conjunction with the shell flipper, both developed at Lawrence Livermore National Laboratory, allowed for full mapping of shell surfaces by mounting corresponding hemispheres onto the PSDI within a 2-deg accuracy.