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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
Jung-Sik Yoon, Mi-Young Song, Young-Woo Kim
Fusion Science and Technology | Volume 55 | Number 2 | February 2009 | Pages 71-75
Technical Paper | Seventh International Conference on Open Magnetic Systems for Plasma Confinement | dx.doi.org/10.13182/FST09-A6985
Articles are hosted by Taylor and Francis Online.
Eikonal approximation is applied to investigate the elastic electron-ion collisions in dense high -temperature plasmas. The longitudinal dielectric function is applied to describe the interaction potential in dense, high-temperature plasmas. The straight-line trajectory approximation is applied to the motion of the projectile electron in order to investigte the variation of the eikonal phase as a function of impact parameter and plasma parameters. The results show that the eikonal differential elastic cross section substantially decrease with the increase of the velocity ratio [overbar]v(𠼩>vT/v), i.e., increasing the electron thermal velocity. For a given velocity ratio, the eikonal cross section is increasing with the including the quantum mechanical effects. It is also found that the maximum position of the eikonal differential elastic cross section has receded from the target ion core as the velocity ratio [overbar]v decrease.