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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
T. P. Bernat, D. N. Bittner, S. Carter, B. Lawson, B. Motta, N. Petta, S. Phommarine
Fusion Science and Technology | Volume 55 | Number 3 | April 2009 | Pages 343-348
Technical Paper | Eighteenth Target Fabrication Specialists' Meeting | dx.doi.org/10.13182/FST09-A6961
Articles are hosted by Taylor and Francis Online.
Indirect-drive ignition targets require that the hohlraums contain a gas of helium, hydrogen, or a mixture of the two. For this purpose, thin polyimide windows must cover the laser entrance holes and any other hohlraum ports. We have fabricated, assembled, and tested such windows and have measured their deflection as a function of applied pressure. We also measured the permeation of helium through them. We find that the deflection is approximately linear with pressure and that the two polyimide formulations that we tested are internally consistent as well as consistent with the earlier data of Powell and Lopez when scaled for geometry. We also find that the permeation is linear with pressure, despite the large increase in window area-to-thickness ratio that occurs during a measurement run that results from the window deflection and thinning as the pressure increases. The permeability of our spin-cast material is 0.65 × 10-13 sccs/cmPa, with an uncertainty of 15% (sccs = standard cubic centimeters per second).