A fusion prototypic neutron source (FPNS) will play a fundamental role in testing and developing fusion materials that can withstand the harsh fusion environment. A thorough assessment is conducted to determine whether blanket materials would benefit from FPNS testing. Because of the cross sections for the various blanket materials, lithium-containing materials can generally be tested adequately using existing fission irradiation capabilities instead of waiting for or relying solely on future FPNS experiments. However, non-lithium blanket materials, such as beryllium multipliers and flow channel inserts, should be tested under a fusion neutron spectrum.