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Radium sources yield cancer-fighting Ac-225 in IAEA program
The International Atomic Energy Agency has reported that, to date, 14 countries have made 14 transfers of disused radium to be recycled for use in advanced cancer treatments under the agency’s Global Radium-226 Management Initiative. Through this initiative, which was launched in 2021, legacy radium-226 from decades-old medical and industrial sources is used to produce actinium-225 radiopharmaceuticals, which have shown effectiveness in the treatment of patients with breast and prostate cancer and certain other cancers.
Ander Gray, Andrew Davis, Edoardo Patelli
Fusion Science and Technology | Volume 77 | Number 7 | November 2021 | Pages 802-812
Technical Paper | doi.org/10.1080/15361055.2021.1895667
Articles are hosted by Taylor and Francis Online.
In this paper we perform nuclear data uncertain propagation with Total Monte Carlo, where the transport simulation is repeated for random evaluations of the data. The Oktavian Iron, Oktavian Nickel, and the Frascati Neutron Generator (FNG) neutron streaming SINBAD benchmarks were evaluated with OpenMC. Gaussian random deviates were drawn from the ENDF/B-VII.1 and TENDL-2017 libraries where the covariances were available. Uncertainty from multiple nuclides was propagated simultaneously assuming inter-nuclide independence. When the individual statistical uncertainty is negligible compared to the data uncertainty, then standard probability theory may be applied. If this is not the case and both need to be considered, we use Imprecise Probabilities (IP) to perform further analysis. We show how uncertain experimental data may be compared to uncertain simulation in the context of IP, and show how an uncertainty-based sensitivity analysis can be performed with IP.