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Fusion Science and Technology
Researchers report fastest purification of astatine-211 needed for targeted cancer therapy
Astatine-211 recovery from bismuth metal using a chromatography system. Unlike bismuth, astatine-211 forms chemical bonds with ketones.
In a recent study, Texas A&M University researchers have described a new process to purify astatine-211, a promising radioactive isotope for targeted cancer treatment. Unlike other elaborate purification methods, their technique can extract astatine-211 from bismuth in minutes rather than hours, which can greatly reduce the time between production and delivery to the patient.
“Astatine-211 is currently under evaluation as a cancer therapeutic in clinical trials. But the problem is that the supply chain for this element is very limited because only a few places worldwide can make it,” said Jonathan Burns, research scientist in the Texas A&M Engineering Experiment Station’s Nuclear Engineering and Science Center. “Texas A&M University is one of a handful of places in the world that can make astatine-211, and we have delineated a rapid astatine-211 separation process that increases the usable quantity of this isotope for research and therapeutic purposes.”
The researchers added that this separation method will bring Texas A&M one step closer to being able to provide astatine-211 for distribution through the Department of Energy’s Isotope Program’s National Isotope Development Center as part of the University Isotope Network.
Details on the chemical reaction to purify astatine-211 are in the journal Separation and Purification Technology.
E. Loomis, S. R. Greenfield, S. N. Luo, R. Johnson, T. Shimada, J. Cobble, A. Seifter, D. S. Montgomery
Fusion Science and Technology | Volume 55 | Number 2 | February 2009 | Pages 152-162
Technical Paper | dx.doi.org/10.13182/FST09-A4068
Articles are hosted by Taylor and Francis Online.
Single crystals of beryllium were illuminated with nanosecond X-ray pulses generated from laser irradiated (~1.5 × 1014 W/cm2) gold targets. The characteristic gold M-band centered at 2.5 keV was measured by time-integrated transmission grating spectroscopy and a time-resolved (spectrally integrated) X-ray photodiode through beryllium targets of various thickness. Approximately decaying exponential temperature profiles were predicted to be induced in 100- and 160-m-thick single crystal targets producing nearly instant surface motion as measured by free surface velocity interferometry. This temperature profile gave rise to free surface (opposite to drive laser surface) velocity histories in a c-axis single crystal and a (10[overbar]10) single crystal in which large initial acceleration gave way to lower (ramped) acceleration due to the internal temperature gradient. A smooth rise to the peak velocity was then followed by a sharp release originating from the free surface nearest to the laser drive. Differences between the velocities in each of these regions were found between the two single crystals investigated, which were due to the thermal expansion properties as a function of direction (including plasticity). These results can be used to predict the behavior of preheated polycrystalline targets relevant to instability seeding in inertial confinement fusion ablators.