A detailed two-dimensional nucleonic analysis was performed for a conceptual first wall, blanket, and shield design for the Compact Reversed-Field Pinch Keactor. The design includes significant two-dimensional aspects presented by the limiter, vacuum ducts, and coolant manifolds; these aspects seriously degrade the tritium-breeding reaction (TBR) predicted by one-dimensional calculations. A range of design change to increase the TBR were investigated within the two-dimensional analysis. The results of this investigation indicated that an adequate TBR could be achieved with a thinner copper first wall, a 6Li enrichment near 90%, the proper selection of reflector, and a small addition to the blanekt thickness, determined by the one-dimensional analysis.