The Mirror Advanced Reactor Study (MARS) is a conceptual design study for a commercial fusion power reactor. One of the major goals of MARS is to develop design guidance so that fusion reactors can meet reasonable expectations for environmental health and safety. One of the first steps in the assessment of health and safety requirements was to examine what the guidelines might be for health and safety in disposal of radioactive wastes from fusion reactors. Then, using these guidelines as criteria, the impact of materials selection upon generation of radioactive wastes through neutron activation of structural materials was investigated. A conclusion of this work is that fusion power systems may need substantial engineering effort in new materials development and selection to meet the probable publicly acceptable levels of radioactivity for waste disposal in the future.