A quantitative comparison of the physics and technology requirements, and the cost and safety performance of a d-d tokamak relative to a d-t tokamak has been performed. The first wall/blanket and energy recovery cycle for the d-d tokamak is simpler, and has a higher efficiency than the d-t tokamak. In most other technology areas (such as magnets, RF, vacuum, etc.) d-d requirements are more severe and the systems are more complex, expensive and may involve higher technical risk than d-t tokamak systems. Tritium technology for processing the plasma exhaust, and tritium refueling technology are required for d-d reactors, but no tritium containment around the blanket or heat transport system is needed. Cost studies show that for high plasma beta and high magnetic field the cost of electricity from d-d and d-t tokamaks is comparable. Safety analysis shows less radioactivity in a d-d reactor but larger amounts of stored energy and thus higher potential for energy release. Consequences of all postulated d-d accidents are significantly smaller than those from d-t reactor tritium releases.